Carnitine O-acetyltransferase

carnitine O-acetyltransferase
Identifiers
EC number 2.3.1.7
CAS number 9029-90-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a carnitine O-acetyltransferase (EC 2.3.1.7) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + carnitine \rightleftharpoons CoA + O-acetylcarnitine

Thus, the two substrates of this enzyme are acetyl-CoA and carnitine, whereas its two products are CoA and O-acetylcarnitine.

This enzyme belongs to the family of transferases, to be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:carnitine O-acetyltransferase. Other names in common use include acetyl-CoA-carnitine O-acetyltransferase, acetylcarnitine transferase, carnitine acetyl coenzyme A transferase, carnitine acetylase, carnitine acetyltransferase, carnitine-acetyl-CoA transferase, and CATC. This enzyme participates in alanine and aspartate metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1NDB, 1NDF, 1NDI, 1NM8, 1S5O, 1T7O, and 1T7Q.

References